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Cyclin D activates the Rb tumor suppressor by mono-phosphorylation
The widely accepted model of G(1) cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G(1) phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors. However, this model remains unproven biochemical...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076869/ https://www.ncbi.nlm.nih.gov/pubmed/24876129 http://dx.doi.org/10.7554/eLife.02872 |