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Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

The widely accepted model of G(1) cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G(1) phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors. However, this model remains unproven biochemical...

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Detalles Bibliográficos
Autores principales:	Narasimha, Anil M, Kaulich, Manuel, Shapiro, Gary S, Choi, Yoon J, Sicinski, Piotr, Dowdy, Steven F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076869/ https://www.ncbi.nlm.nih.gov/pubmed/24876129 http://dx.doi.org/10.7554/eLife.02872

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