High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets

High pathogenicity avian influenza viruses (HPAIV) have caused fatal infections in mammals through consumption of infected bird carcasses or meat, but scarce information exists on the dose of virus required and the diversity of HPAIV subtypes involved. Ferrets were exposed to different HPAIV (H5 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Bertran, Kateri, Swayne, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077040/
https://www.ncbi.nlm.nih.gov/pubmed/24894438
http://dx.doi.org/10.1186/1297-9716-45-60
_version_ 1782323551723847680
author Bertran, Kateri
Swayne, David E
author_facet Bertran, Kateri
Swayne, David E
author_sort Bertran, Kateri
collection PubMed
description High pathogenicity avian influenza viruses (HPAIV) have caused fatal infections in mammals through consumption of infected bird carcasses or meat, but scarce information exists on the dose of virus required and the diversity of HPAIV subtypes involved. Ferrets were exposed to different HPAIV (H5 and H7 subtypes) through consumption of infected chicken meat. The dose of virus needed to infect ferrets through consumption was much higher than via respiratory exposure and varied with the virus strain. In addition, H5N1 HPAIV produced higher titers in the meat of infected chickens and more easily infected ferrets than the H7N3 or H7N7 HPAIV.
format Online
Article
Text
id pubmed-4077040
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-40770402014-07-02 High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets Bertran, Kateri Swayne, David E Vet Res Short Report High pathogenicity avian influenza viruses (HPAIV) have caused fatal infections in mammals through consumption of infected bird carcasses or meat, but scarce information exists on the dose of virus required and the diversity of HPAIV subtypes involved. Ferrets were exposed to different HPAIV (H5 and H7 subtypes) through consumption of infected chicken meat. The dose of virus needed to infect ferrets through consumption was much higher than via respiratory exposure and varied with the virus strain. In addition, H5N1 HPAIV produced higher titers in the meat of infected chickens and more easily infected ferrets than the H7N3 or H7N7 HPAIV. BioMed Central 2014 2014-06-03 /pmc/articles/PMC4077040/ /pubmed/24894438 http://dx.doi.org/10.1186/1297-9716-45-60 Text en Copyright © 2014 Bertran and Swayne; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Bertran, Kateri
Swayne, David E
High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
title High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
title_full High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
title_fullStr High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
title_full_unstemmed High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
title_short High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
title_sort high doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077040/
https://www.ncbi.nlm.nih.gov/pubmed/24894438
http://dx.doi.org/10.1186/1297-9716-45-60
work_keys_str_mv AT bertrankateri highdosesofhighlypathogenicavianinfluenzavirusinchickenmeatarerequiredtoinfectferrets
AT swaynedavide highdosesofhighlypathogenicavianinfluenzavirusinchickenmeatarerequiredtoinfectferrets

Ejemplares similares