Substantially increased sildenafil bioavailability after sublingual administration in children with congenital heart disease: two case reports

INTRODUCTION: Pulmonary hypertension is a progressive disease of diverse origin with devastating consequences in adults as well as in children. The phosphodiesterase 5 inhibitor sildenafil successfully lowers pulmonary vascular resistance. However, because of its poor enteral absorption, resulting i...

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Detalles Bibliográficos
Autores principales: Carls, Alexandra, Winter, Julia, Enderle, Yeliz, Burhenne, Jürgen, Gorenflo, Matthias, Haefeli, Walter E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077237/
https://www.ncbi.nlm.nih.gov/pubmed/24885923
http://dx.doi.org/10.1186/1752-1947-8-171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077237/
https://www.ncbi.nlm.nih.gov/pubmed/24885923
http://dx.doi.org/10.1186/1752-1947-8-171

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