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Substantially increased sildenafil bioavailability after sublingual administration in children with congenital heart disease: two case reports

INTRODUCTION: Pulmonary hypertension is a progressive disease of diverse origin with devastating consequences in adults as well as in children. The phosphodiesterase 5 inhibitor sildenafil successfully lowers pulmonary vascular resistance. However, because of its poor enteral absorption, resulting i...

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Detalles Bibliográficos
Autores principales:	Carls, Alexandra, Winter, Julia, Enderle, Yeliz, Burhenne, Jürgen, Gorenflo, Matthias, Haefeli, Walter E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077237/ https://www.ncbi.nlm.nih.gov/pubmed/24885923 http://dx.doi.org/10.1186/1752-1947-8-171

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