A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids

We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral α-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic α-keto esters. The possible mechanism is...

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Detalles Bibliográficos
Autores principales: Duan, Zhiqiang, Han, Jianlin, Qian, Ping, Zhang, Zirui, Wang, Yi, Pan, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077541/
https://www.ncbi.nlm.nih.gov/pubmed/24991246
http://dx.doi.org/10.3762/bjoc.10.95

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077541/
https://www.ncbi.nlm.nih.gov/pubmed/24991246
http://dx.doi.org/10.3762/bjoc.10.95

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