Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

BACKGROUND: Having the apolipoprotein E4 (APOE-ϵ4) allele is the strongest genetic risk factor for the development of Alzheimer’s disease (AD). Accumulation of amyloid beta (Aβ) in the brain is influenced by APOE genotype. Transgenic mice co-expressing five familial AD mutations (5xFAD) in the prese...

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Detalles Bibliográficos
Autores principales: Rodriguez, Gustavo A, Tai, Leon M, LaDu, Mary Jo, Rebeck, G William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077554/
https://www.ncbi.nlm.nih.gov/pubmed/24948358
http://dx.doi.org/10.1186/1742-2094-11-111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077554/
https://www.ncbi.nlm.nih.gov/pubmed/24948358
http://dx.doi.org/10.1186/1742-2094-11-111

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