Cargando…

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

BACKGROUND: Having the apolipoprotein E4 (APOE-ϵ4) allele is the strongest genetic risk factor for the development of Alzheimer’s disease (AD). Accumulation of amyloid beta (Aβ) in the brain is influenced by APOE genotype. Transgenic mice co-expressing five familial AD mutations (5xFAD) in the prese...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodriguez, Gustavo A, Tai, Leon M, LaDu, Mary Jo, Rebeck, G William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077554/ https://www.ncbi.nlm.nih.gov/pubmed/24948358 http://dx.doi.org/10.1186/1742-2094-11-111

Ejemplares similares

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
por: Tai, Leon M, et al.
Publicado: (2014)

Introducing Human APOE into Aβ Transgenic Mouse Models
por: Tai, Leon M., et al.
Publicado: (2011)

Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE
por: Ng, Christi Anne S., et al.
Publicado: (2022)

The generation and function of soluble apoE receptors in the CNS
por: Rebeck, G William, et al.
Publicado: (2006)

ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro
por: Nwabuisi-Heath, Evelyn, et al.
Publicado: (2014)

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation
por: Cherry, Jonathan D., et al.
Publicado: (2015)

APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective
por: Tai, Leon M., et al.
Publicado: (2015)

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
por: Colombo, Alessio Vittorio, et al.
Publicado: (2021)

APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice
por: Stephen, T. L., et al.
Publicado: (2019)

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease
por: Zhao, Ruohe, et al.
Publicado: (2017)

Endocytic pathways mediating oligomeric Aβ42 neurotoxicity
por: Yu, Chunjiang, et al.
Publicado: (2010)

Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro
por: Ghura, Shivesh, et al.
Publicado: (2016)

Transcriptional signature in microglia associated with Aβ plaque phagocytosis
por: Grubman, Alexandra, et al.
Publicado: (2021)

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques
por: Natunen, Teemu, et al.
Publicado: (2020)

Murine Gut Microbiome Association With APOE Alleles
por: Parikh, Ishita J., et al.
Publicado: (2020)

ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
por: Caesar, Ina, et al.
Publicado: (2023)

APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice
por: Balu, Deebika, et al.
Publicado: (2023)

ApoE isoform-dependent changes in hippocampal synaptic function
por: Korwek, Kimberly M, et al.
Publicado: (2009)

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
por: Mahan, Thomas E., et al.
Publicado: (2022)

ApoE mimetic peptide decreases Aβ production in vitro and in vivo
por: Minami, S Sakura, et al.
Publicado: (2010)

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
por: Huynh, Tien-Phat V., et al.
Publicado: (2019)

Genetics ignite focus on microglial inflammation in Alzheimer’s disease
por: Malik, Manasi, et al.
Publicado: (2015)

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
por: Youmans, Katherine L, et al.
Publicado: (2012)

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
por: Maldonado Weng, Juan, et al.
Publicado: (2019)

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
por: Ferrari-Souza, João Pedro, et al.
Publicado: (2023)

3367 A Mouse Model of APOE Genotype in Chemotherapy Related Cognitive Impairment
por: Demby, Tamar, et al.
Publicado: (2019)

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease
por: Wolf, Andrew B, et al.
Publicado: (2013)

Seed‐induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease
por: Ziegler‐Waldkirch, Stephanie, et al.
Publicado: (2017)

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
por: Lim, Carine Z. J., et al.
Publicado: (2019)

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
por: Shi, Yang, et al.
Publicado: (2019)

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading
por: Wang, Chanung, et al.
Publicado: (2023)

Development and validation of a yeast high-throughput screen for inhibitors of Aβ(42) oligomerization
por: Park, Sei-Kyoung, et al.
Publicado: (2011)

NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-β neuropathology in transgenic models of Alzheimer’s disease
por: Thatcher, Gregory RJ, et al.
Publicado: (2013)

Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice
por: Hemonnot-Girard, Anne-Laure, et al.
Publicado: (2022)

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
por: Condello, Carlo, et al.
Publicado: (2015)

Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain
por: Marinelli, Rita, et al.
Publicado: (2020)

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Wright, Amanda L., et al.
Publicado: (2013)

The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
por: Jones, Nahdia S., et al.
Publicado: (2018)

APOE4 confers transcriptomic and functional alterations to primary mouse microglia
por: Machlovi, Saima I., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mb4gvho33ttphjfsdncj42uldo