Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin...

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Detalles Bibliográficos
Autores principales: Sleebs, Brad E., Lopaticki, Sash, Marapana, Danushka S., O'Neill, Matthew T., Rajasekaran, Pravin, Gazdik, Michelle, Günther, Svenja, Whitehead, Lachlan W., Lowes, Kym N., Barfod, Lea, Hviid, Lars, Shaw, Philip J., Hodder, Anthony N., Smith, Brian J., Cowman, Alan F., Boddey, Justin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077696/
https://www.ncbi.nlm.nih.gov/pubmed/24983235
http://dx.doi.org/10.1371/journal.pbio.1001897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077696/
https://www.ncbi.nlm.nih.gov/pubmed/24983235
http://dx.doi.org/10.1371/journal.pbio.1001897

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