AKT Pathway Genes Define 5 Prognostic Subgroups in Glioblastoma

Activity of GFR/PI3K/AKT pathway inhibitors in glioblastoma clinical trials has not been robust. We hypothesized variations in the pathway between tumors contribute to poor response. We clustered GBM based on AKT pathway genes and discovered new subtypes then characterized their clinical and molecul...

Descripción completa

Detalles Bibliográficos
Autores principales: Joy, Anna, Ramesh, Archana, Smirnov, Ivan, Reiser, Mark, Misra, Anjan, Shapiro, William R., Mills, Gordon B., Kim, Seungchan, Feuerstein, Burt G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077731/
https://www.ncbi.nlm.nih.gov/pubmed/24984002
http://dx.doi.org/10.1371/journal.pone.0100827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077731/
https://www.ncbi.nlm.nih.gov/pubmed/24984002
http://dx.doi.org/10.1371/journal.pone.0100827

Ejemplares similares