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AKT Pathway Genes Define 5 Prognostic Subgroups in Glioblastoma

Activity of GFR/PI3K/AKT pathway inhibitors in glioblastoma clinical trials has not been robust. We hypothesized variations in the pathway between tumors contribute to poor response. We clustered GBM based on AKT pathway genes and discovered new subtypes then characterized their clinical and molecul...

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Detalles Bibliográficos
Autores principales:	Joy, Anna, Ramesh, Archana, Smirnov, Ivan, Reiser, Mark, Misra, Anjan, Shapiro, William R., Mills, Gordon B., Kim, Seungchan, Feuerstein, Burt G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077731/ https://www.ncbi.nlm.nih.gov/pubmed/24984002 http://dx.doi.org/10.1371/journal.pone.0100827

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