cAMP Control of HCN2 Channel Mg(2+) Block Reveals Loose Coupling between the Cyclic Nucleotide-Gating Ring and the Pore

Hyperpolarization-activated cyclic nucleotide-regulated HCN channels underlie the Na(+)-K(+) permeable I(H) pacemaker current. As with other voltage-gated members of the 6-transmembrane K(V) channel superfamily, opening of HCN channels involves dilation of a helical bundle formed by the intracellula...

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Detalles Bibliográficos
Autores principales: Lyashchenko, Alex K., Redd, Kacy J., Goldstein, Peter A., Tibbs, Gareth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077740/
https://www.ncbi.nlm.nih.gov/pubmed/24983358
http://dx.doi.org/10.1371/journal.pone.0101236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077740/
https://www.ncbi.nlm.nih.gov/pubmed/24983358
http://dx.doi.org/10.1371/journal.pone.0101236

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