The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence

Oncogene induced senescence (OIS) is a sustained anti-proliferative response acutely induced in primary cells via activation of mitogenic oncogenes such as Ras/BRAF. This mechanism acts as an initial barrier preventing normal cells transformation into malignant cell. Besides oncogenic activation and...

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Detalles Bibliográficos
Autores principales: Kilic Eren, Mehtap, Tabor, Vedrana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077769/
https://www.ncbi.nlm.nih.gov/pubmed/24984035
http://dx.doi.org/10.1371/journal.pone.0101064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077769/
https://www.ncbi.nlm.nih.gov/pubmed/24984035
http://dx.doi.org/10.1371/journal.pone.0101064

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