Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

The optineurin gene, OPTN, is one of the causative genes of primary open-angle glaucoma. Although oligomerization of optineurin in cultured cells was previously observed by gel filtration analysis and blue native gel electrophoresis (BNE), little is known about the characteristics of optineurin olig...

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Detalles Bibliográficos
Autores principales: Gao, Jie, Ohtsubo, Masafumi, Hotta, Yoshihiro, Minoshima, Shinsei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077773/
https://www.ncbi.nlm.nih.gov/pubmed/24983867
http://dx.doi.org/10.1371/journal.pone.0101206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077773/
https://www.ncbi.nlm.nih.gov/pubmed/24983867
http://dx.doi.org/10.1371/journal.pone.0101206

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