Cargando…

Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

The optineurin gene, OPTN, is one of the causative genes of primary open-angle glaucoma. Although oligomerization of optineurin in cultured cells was previously observed by gel filtration analysis and blue native gel electrophoresis (BNE), little is known about the characteristics of optineurin olig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Jie, Ohtsubo, Masafumi, Hotta, Yoshihiro, Minoshima, Shinsei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077773/ https://www.ncbi.nlm.nih.gov/pubmed/24983867 http://dx.doi.org/10.1371/journal.pone.0101206

Ejemplares similares

A Japanese family with cone-rod dystrophy of delayed onset caused by a compound heterozygous combination of novel CDHR1 frameshift and known missense variants
por: Haque, Muhammad Nazmul, et al.
Publicado: (2019)

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma
por: Toth, Reka P., et al.
Publicado: (2018)

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin
por: Swarup, Ghanshyam, et al.
Publicado: (2018)

Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma
por: Liu, Yutao, et al.
Publicado: (2008)

Absence of altered expression of optineurin in primary open angle glaucoma patients
por: Abu-Amero, Khaled K., et al.
Publicado: (2012)

Molecular analysis of myocilin and optineurin genes in Korean primary glaucoma patients
por: Park, Joonhong, et al.
Publicado: (2016)

Novel GUCY2D Gene Mutations in Japanese Male Twins with Leber Congenital Amaurosis
por: Hosono, Katsuhiro, et al.
Publicado: (2015)

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin
por: Sirohi, Kapil, et al.
Publicado: (2015)

Posttranslational Modifications, Localization, and Protein Interactions of Optineurin, the Product of a Glaucoma Gene
por: Ying, Hongyu, et al.
Publicado: (2010)

Coding Region Mutation Screening in Optineurin in Chinese Normal-Tension Glaucoma Patients
por: He, Jing Na, et al.
Publicado: (2019)

Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve
por: Jeong, Yaeram, et al.
Publicado: (2023)

Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration
por: Shim, Myoung Sup, et al.
Publicado: (2016)

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice
por: Chi, Zai-Long, et al.
Publicado: (2010)

Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration
por: Shim, Myoung Sup, et al.
Publicado: (2017)

Microarray expression profile analysis of long non-coding RNAs in optineurin E50K mutant transgenic mice
por: Li, Yuanyuan, et al.
Publicado: (2017)

Optineurin Functions for Optimal Immunity
por: Slowicka, Karolina, et al.
Publicado: (2018)

Absence of optineurin (OPTN) gene mutations in Taiwanese patients with juvenile-onset open-angle glaucoma
por: Yen, Yung-Chang, et al.
Publicado: (2008)

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant
por: Nagabhushana, Ananthamurthy, et al.
Publicado: (2010)

A novel optineurin genetic mutation associated with open-angle glaucoma in a Chinese family
por: Xiao, Zheng, et al.
Publicado: (2009)

Novel OPN1LW/OPN1MW deletion mutations in 2 Japanese families with blue cone monochromacy
por: Wang, Chunxia, et al.
Publicado: (2016)

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis
por: Sahlender, Daniela A., et al.
Publicado: (2005)

The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro
por: Zhang, Shiqi, et al.
Publicado: (2021)

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis
por: Chew, Thean S., et al.
Publicado: (2015)

Effects of mutations and deletions in the human optineurin gene
por: Turturro, Sanja, et al.
Publicado: (2014)

The Selective Autophagy Receptor Optineurin in Crohn’s Disease
por: Tschurtschenthaler, Markus, et al.
Publicado: (2018)

Detection of Epidermal Growth Factor Receptor Gene Amplification in Human Squamous Cell Carcinomas Using Fluorescence in situ Hybridization
por: Shimizu, Nobuyoshi, et al.
Publicado: (1994)

Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin
por: Park, BumChan, et al.
Publicado: (2010)

The Role of Optineurin in Antiviral Type I Interferon Production
por: Outlioua, Ahmed, et al.
Publicado: (2018)

Editorial: The Role of Optineurin in Immunity and Immune-Mediated Diseases
por: Smith, Andrew M., et al.
Publicado: (2019)

Covalently Linking Oligomerization-Impaired GlpF Protomers Does Not Completely Re-establish Wild-Type Channel Activity
por: Klein, Noreen, et al.
Publicado: (2019)

Variation in optineurin (OPTN) allele frequencies between and within populations
por: Ayala-Lugo, Rosa M., et al.
Publicado: (2007)

Myocilin and optineurin coding variants in Hispanics of Mexican Descent with POAG
por: McDonald, Kristin K., et al.
Publicado: (2010)

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy
por: Ryan, Thomas A., et al.
Publicado: (2018)

Novel mutation in optineurin causing aggressive ALS+/−frontotemporal dementia
por: Feng, Shu‐Man, et al.
Publicado: (2019)

PINK1‐mediated mitophagy maintains pluripotency through optineurin
por: Wang, Chaoqun, et al.
Publicado: (2021)

Neuroimmune characterization of optineurin insufficiency mouse model during ageing
por: Mohovic, Nikolina, et al.
Publicado: (2023)

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively
por: Sayyad, Zuberwasim, et al.
Publicado: (2017)

Two Novel Mutations in the EYS Gene Are Possible Major Causes of Autosomal Recessive Retinitis Pigmentosa in the Japanese Population
por: Hosono, Katsuhiro, et al.
Publicado: (2012)

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division
por: Petracchini, Serena, et al.
Publicado: (2022)

Myosin VI and Optineurin Are Required for Polarized EGFR Delivery and Directed Migration
por: Chibalina, Margarita V, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_nl0sdlo9tuvbpt7k8bgrio7bge