The Rational Design of Specific Peptide Inhibitor against p38α MAPK at Allosteric-Site: A Therapeutic Modality for HNSCC

p38α is a significant target for drug designing against cancer. The overproduction of p38α MAPK promotes tumorigenesis in head and neck squamous cell carcinoma (HNSCC). The ATP binding and an allosteric site referred as DFG are the key sites of the p38α mitogen activated protein kinase (MAPK) exploi...

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Detalles Bibliográficos
Autores principales: Gill, Kamaldeep, Nigam, Lokesh, Singh, Ratnakar, Kumar, Suresh, Subbarao, Naidu, Chauhan, Shyam Singh, Dey, Sharmistha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077802/
https://www.ncbi.nlm.nih.gov/pubmed/24983631
http://dx.doi.org/10.1371/journal.pone.0101525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077802/
https://www.ncbi.nlm.nih.gov/pubmed/24983631
http://dx.doi.org/10.1371/journal.pone.0101525

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