Conserved Prosegment Residues Stabilize a Late-Stage Folding Transition State of Pepsin Independently of Ground States

The native folding of certain zymogen-derived enzymes is completely dependent upon a prosegment domain to stabilize the folding transition state, thereby catalyzing the folding reaction. Generally little is known about how the prosegment accomplishes this task. It was previously shown that the prose...

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Detalles Bibliográficos
Autores principales: Dee, Derek R., Horimoto, Yasumi, Yada, Rickey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077824/
https://www.ncbi.nlm.nih.gov/pubmed/24983988
http://dx.doi.org/10.1371/journal.pone.0101339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077824/
https://www.ncbi.nlm.nih.gov/pubmed/24983988
http://dx.doi.org/10.1371/journal.pone.0101339

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