A Genome-Wide RNAi Screen Identifies FOXO4 as a Metastasis-Suppressor through Counteracting PI3K/AKT Signal Pathway in Prostate Cancer

Activation of the PI3K/AKT signal pathway is a known driving force for the progression to castration-recurrent prostate cancer (CR-CaP), which constitutes the major lethal phenotype of CaP. Here, we identify using a genomic shRNA screen the PI3K/AKT-inactivating downstream target, FOXO4, as a potent...

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Detalles Bibliográficos
Autores principales: Su, Bing, Gao, Lingqiu, Baranowski, Catherine, Gillard, Bryan, Wang, Jianmin, Ransom, Ryan, Ko, Hyun-Kyung, Gelman, Irwin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077825/
https://www.ncbi.nlm.nih.gov/pubmed/24983969
http://dx.doi.org/10.1371/journal.pone.0101411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077825/
https://www.ncbi.nlm.nih.gov/pubmed/24983969
http://dx.doi.org/10.1371/journal.pone.0101411

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