FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J

BACKGROUND: Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch activation have not been successful. Many limitations, such as non-Notch specifi...

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Detalles Bibliográficos
Autores principales: Fu, Wei, Wang, Kai, Zhao, Jun-Long, Yu, Heng-Chao, Li, San-Zhong, Lin, Yan, Liang, Liang, Huang, Si-Yong, Liang, Ying-Min, Han, Hua, Qin, Hong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077834/
https://www.ncbi.nlm.nih.gov/pubmed/24952875
http://dx.doi.org/10.1186/1471-2407-14-463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077834/
https://www.ncbi.nlm.nih.gov/pubmed/24952875
http://dx.doi.org/10.1186/1471-2407-14-463

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