Cargando…
FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J
BACKGROUND: Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch activation have not been successful. Many limitations, such as non-Notch specifi...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077834/ https://www.ncbi.nlm.nih.gov/pubmed/24952875 http://dx.doi.org/10.1186/1471-2407-14-463 |