Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

In phagocytic cells, including the retinal pigment epithelium (RPE), acidic compartments of the endolysosomal system are regulators of both phagocytosis and autophagy, thereby helping to maintain cellular homeostasis. The acidification of the endolysosomal system is modulated by a proton pump, the V...

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Detalles Bibliográficos
Autores principales: Valapala, Mallika, Wilson, Christine, Hose, Stacey, Bhutto, Imran A, Grebe, Rhonda, Dong, Aling, Greenbaum, Seth, Gu, Limin, Sengupta, Samhita, Cano, Marisol, Hackett, Sean, Xu, Guotong, Lutty, Gerard A, Dong, Lijin, Sergeev, Yuri, Handa, James T, Campochiaro, Peter, Wawrousek, Eric, Zigler, Jr, J Samuel, Sinha, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077886/
https://www.ncbi.nlm.nih.gov/pubmed/24468901
http://dx.doi.org/10.4161/auto.27292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077886/
https://www.ncbi.nlm.nih.gov/pubmed/24468901
http://dx.doi.org/10.4161/auto.27292

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