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Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development
BACKGROUND: Striking a balance between the degree of model complexity and parameter identifiability, while still producing biologically feasible simulations using modelling is a major challenge in computational biology. While these two elements of model development are closely coupled, parameter fit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078362/ https://www.ncbi.nlm.nih.gov/pubmed/24886522 http://dx.doi.org/10.1186/1752-0509-8-59 |