Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress

BACKGROUND: 3-Hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive inhibitors of the rate-limiting enzyme in cholesterol biosynthesis. Currently, statins are used as first-line therapy in the treatment of diabetic dyslipidemia. However, effects of statins on β cell...

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Detalles Bibliográficos
Autores principales: Chen, Zhi-yu, Liu, Shuai-nan, Li, Cai-na, Sun, Su-juan, Liu, Quan, Lei, Lei, Gao, Li-hui, Shen, Zhu-fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078942/
https://www.ncbi.nlm.nih.gov/pubmed/24950764
http://dx.doi.org/10.1186/1476-511X-13-98

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078942/
https://www.ncbi.nlm.nih.gov/pubmed/24950764
http://dx.doi.org/10.1186/1476-511X-13-98

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