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Weak Negative and Positive Selection and the Drift Load at Splice Sites
Splice sites (SSs) are short sequences that are crucial for proper mRNA splicing in eukaryotic cells, and therefore can be expected to be shaped by strong selection. Nevertheless, in mammals and in other intron-rich organisms, many of the SSs often involve nonconsensus (Nc), rather than consensus (C...
Autores principales: | Denisov, Stepan V., Bazykin, Georgii A., Sutormin, Roman, Favorov, Alexander V., Mironov, Andrey A., Gelfand, Mikhail S., Kondrashov, Alexey S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079205/ https://www.ncbi.nlm.nih.gov/pubmed/24966225 http://dx.doi.org/10.1093/gbe/evu100 |
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