A Linear Relationship between Crystal Size and Fragment Binding Time Observed Crystallographically: Implications for Fragment Library Screening Using Acoustic Droplet Ejection

High throughput screening technologies such as acoustic droplet ejection (ADE) greatly increase the rate at which X-ray diffraction data can be acquired from crystals. One promising high throughput screening application of ADE is to rapidly combine protein crystals with fragment libraries. In this a...

Descripción completa

Detalles Bibliográficos
Autores principales: Cole, Krystal, Roessler, Christian G., Mulé, Elizabeth A., Benson-Xu, Emma J., Mullen, Jeffrey D., Le, Benjamin A., Tieman, Alanna M., Birone, Claire, Brown, Maria, Hernandez, Jesus, Neff, Sherry, Williams, Daniel, Allaire, Marc, Orville, Allen M., Sweet, Robert M., Soares, Alexei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079544/
https://www.ncbi.nlm.nih.gov/pubmed/24988328
http://dx.doi.org/10.1371/journal.pone.0101036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079544/
https://www.ncbi.nlm.nih.gov/pubmed/24988328
http://dx.doi.org/10.1371/journal.pone.0101036

Ejemplares similares