Cargando…

Unbiased Estimation of Mutation Rates under Fluctuating Final Counts

Estimation methods for mutation rates (or probabilities) in Luria-Delbrück fluctuation analysis usually assume that the final number of cells remains constant from one culture to another. We show that this leads to systematically underestimate the mutation rate. Two levels of information on final nu...

Descripción completa

Detalles Bibliográficos
Autores principales: Ycart, Bernard, Veziris, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079557/
https://www.ncbi.nlm.nih.gov/pubmed/24988217
http://dx.doi.org/10.1371/journal.pone.0101434