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Unbiased Estimation of Mutation Rates under Fluctuating Final Counts
Estimation methods for mutation rates (or probabilities) in Luria-Delbrück fluctuation analysis usually assume that the final number of cells remains constant from one culture to another. We show that this leads to systematically underestimate the mutation rate. Two levels of information on final nu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079557/ https://www.ncbi.nlm.nih.gov/pubmed/24988217 http://dx.doi.org/10.1371/journal.pone.0101434 |