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Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
AIMS/HYPOTHESIS: Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal a...
Autores principales: | Hamilton, D. Lee, Findlay, John A., Montagut, Gemma, Meakin, Paul J., Bestow, Dawn, Jalicy, Susan M., Ashford, Michael L. J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079947/ https://www.ncbi.nlm.nih.gov/pubmed/24849570 http://dx.doi.org/10.1007/s00125-014-3269-x |
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