Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two ‘PPXY’ motifs, that...

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Detalles Bibliográficos
Autores principales: Yue, Shen, Tang, Liu-Ya, Tang, Ying, Tang, Yi, Shen, Qiu-Hong, Ding, Jie, Chen, Yan, Zhang, Zengdi, Yu, Ting-Ting, Zhang, Ying E, Cheng, Steven Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080449/
https://www.ncbi.nlm.nih.gov/pubmed/24925320
http://dx.doi.org/10.7554/eLife.02555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080449/
https://www.ncbi.nlm.nih.gov/pubmed/24925320
http://dx.doi.org/10.7554/eLife.02555

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