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Altered native stability is the dominant basis for susceptibility of α(1)-antitrypsin mutants to polymerization
Serpins are protease inhibitors whose most stable state is achieved upon transition of a central 5-stranded β-sheet to a 6-stranded form. Mutations, low pH, denaturants and elevated temperatures promote this transition, which can result in a growing polymer chain of inactive molecules. Different typ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080824/ https://www.ncbi.nlm.nih.gov/pubmed/24552432 http://dx.doi.org/10.1042/BJ20131650 |