Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations

[Image: see text] The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2) is a critical signal transducer downstream of growth factors that promotes the activation of the RAS-ERK1/2 cascade. In its basal state, SHP2 exists in an autoinhibited closed conformation because of a...

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Detalles Bibliográficos
Autores principales: Yu, Zhi-Hong, Zhang, Ruo-Yu, Walls, Chad D., Chen, Lan, Zhang, Sheng, Wu, Li, Liu, Sijiu, Zhang, Zhong-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081049/
https://www.ncbi.nlm.nih.gov/pubmed/24935154
http://dx.doi.org/10.1021/bi5002695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081049/
https://www.ncbi.nlm.nih.gov/pubmed/24935154
http://dx.doi.org/10.1021/bi5002695

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