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Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations
[Image: see text] The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2) is a critical signal transducer downstream of growth factors that promotes the activation of the RAS-ERK1/2 cascade. In its basal state, SHP2 exists in an autoinhibited closed conformation because of a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081049/ https://www.ncbi.nlm.nih.gov/pubmed/24935154 http://dx.doi.org/10.1021/bi5002695 |