An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells

The E3 ubiquitin ligase RNF168 is a DNA damage response (DDR) factor that promotes monoubiquitination of H2A/H2AX at K13/15, facilitates recruitment of other DDR factors (e.g. 53BP1) to DNA damage, and inhibits homologous recombination (HR) in cells deficient in the tumor suppressor BRCA1. We have e...

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Detalles Bibliográficos
Autores principales: Muñoz, Meilen C., Yanez, Diana A., Stark, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081061/
https://www.ncbi.nlm.nih.gov/pubmed/24829461
http://dx.doi.org/10.1093/nar/gku421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081061/
https://www.ncbi.nlm.nih.gov/pubmed/24829461
http://dx.doi.org/10.1093/nar/gku421

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