Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2

Werner syndrome (WS), caused by loss of function of the RecQ helicase WRN, is a hereditary disease characterized by premature aging and elevated cancer incidence. WRN has DNA binding, exonuclease, ATPase, helicase and strand annealing activities, suggesting possible roles in recombination-related pr...

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Detalles Bibliográficos
Autores principales: Edwards, Deanna N., Orren, David K., Machwe, Amrita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081078/
https://www.ncbi.nlm.nih.gov/pubmed/24880691
http://dx.doi.org/10.1093/nar/gku454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081078/
https://www.ncbi.nlm.nih.gov/pubmed/24880691
http://dx.doi.org/10.1093/nar/gku454

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