Cargando…

Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2

Werner syndrome (WS), caused by loss of function of the RecQ helicase WRN, is a hereditary disease characterized by premature aging and elevated cancer incidence. WRN has DNA binding, exonuclease, ATPase, helicase and strand annealing activities, suggesting possible roles in recombination-related pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edwards, Deanna N., Orren, David K., Machwe, Amrita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081078/ https://www.ncbi.nlm.nih.gov/pubmed/24880691 http://dx.doi.org/10.1093/nar/gku454

Ejemplares similares

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase
por: Nora, Gerald J., et al.
Publicado: (2010)

WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1
por: Sun, Luxi, et al.
Publicado: (2017)

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres
por: Mendez-Bermudez, Aaron, et al.
Publicado: (2012)

Human Rap1 modulates TRF2 attraction to telomeric DNA
por: Janoušková, Eliška, et al.
Publicado: (2015)

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation
por: Iannascoli, Chiara, et al.
Publicado: (2015)

ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance
por: McKerlie, Megan, et al.
Publicado: (2012)

Cockayne Syndrome group B protein interacts with TRF2 and regulates telomere length and stability
por: Batenburg, Nicole L., et al.
Publicado: (2012)

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress
por: Higa, Mitsunori, et al.
Publicado: (2021)

The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging
por: Ying, Yilin, et al.
Publicado: (2022)

Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres
por: Storchova, Radka, et al.
Publicado: (2023)

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events
por: Edwards, Deanna N., et al.
Publicado: (2015)

WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase
por: Chakraborty, Prasun, et al.
Publicado: (2010)

Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage
por: Yang, Lu, et al.
Publicado: (2017)

POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes
por: Rabbani, M A G, et al.
Publicado: (2022)

Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains
por: Machwe, Amrita, et al.
Publicado: (2006)

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase
por: Popuri, Venkateswarlu, et al.
Publicado: (2013)

An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA
por: Haseltine, Cynthia A., et al.
Publicado: (2009)

Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands
por: Min, Jaewon, et al.
Publicado: (2017)

Flanking strand separation activity of RecA nucleoprotein filaments in DNA strand exchange reactions
por: Yu, Fangzhi, et al.
Publicado: (2023)

Replication fork regression in vitro by the Werner syndrome protein (WRN): Holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity
por: Machwe, Amrita, et al.
Publicado: (2007)

Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase
por: Awad, Aya, et al.
Publicado: (2020)

RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease
por: Aiello, Francesca Antonella, et al.
Publicado: (2019)

Telomerase-dependent generation of 70-nt-long telomeric single-stranded 3′ overhangs in yeast
por: Fridholm, Helena, et al.
Publicado: (2013)

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage
por: Rizzo, Angela, et al.
Publicado: (2017)

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE
por: Sen, Doyel, et al.
Publicado: (2016)

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation
por: Lormand, Justin D., et al.
Publicado: (2013)

Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament
por: Fornander, Louise H., et al.
Publicado: (2014)

Bacillus subtilis DisA regulates RecA-mediated DNA strand exchange
por: Torres, Rubén, et al.
Publicado: (2019)

DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe
por: Nandakumar, Jayakrishnan, et al.
Publicado: (2012)

Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks
por: Davé, Anoushka, et al.
Publicado: (2020)

Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection
por: Klebanov-Akopyan, Olga, et al.
Publicado: (2018)

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange
por: Ishida, Takako, et al.
Publicado: (2009)

Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage
por: Kanagaraj, Radhakrishnan, et al.
Publicado: (2012)

Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation
por: McKerlie, Megan, et al.
Publicado: (2013)

Mechanism of Exonuclease I stimulation by the single-stranded DNA-binding protein
por: Lu, Duo, et al.
Publicado: (2011)

A 5′-to-3′ strand exchange polarity is intrinsic to RecA nucleoprotein filaments in the absence of ATP hydrolysis
por: Lin, Yu-Hsuan, et al.
Publicado: (2019)

Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein
por: Yuan, Ying, et al.
Publicado: (2015)

Sld2 binds to origin single-stranded DNA and stimulates DNA annealing
por: Kanter, Diane M., et al.
Publicado: (2011)

ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells
por: Marabitti, Veronica, et al.
Publicado: (2019)

Telomere associated primase Tap repairs truncated telomeres of Streptomyces
por: Yang, Chien-Chin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8ccj3klh7dhfi42har9303e5o1