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A SET-domain-independent role of WRAD complex in cell-cycle regulatory function of mixed lineage leukemia
MLL, the trithorax ortholog, is a well-characterized histone 3 lysine 4 methyltransferase that is crucial for proper regulation of the Hox genes during embryonic development. Chromosomal translocations, disrupting the Mll gene, lead to aggressive leukemia with poor prognosis. However, the functions...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081079/ https://www.ncbi.nlm.nih.gov/pubmed/24880690 http://dx.doi.org/10.1093/nar/gku458 |