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A SET-domain-independent role of WRAD complex in cell-cycle regulatory function of mixed lineage leukemia

MLL, the trithorax ortholog, is a well-characterized histone 3 lysine 4 methyltransferase that is crucial for proper regulation of the Hox genes during embryonic development. Chromosomal translocations, disrupting the Mll gene, lead to aggressive leukemia with poor prognosis. However, the functions...

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Detalles Bibliográficos
Autores principales:	Ali, Aamir, Veeranki, Sailaja Naga, Tyagi, Shweta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081079/ https://www.ncbi.nlm.nih.gov/pubmed/24880690 http://dx.doi.org/10.1093/nar/gku458

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