G-quadruplex conformation and dynamics are determined by loop length and sequence

The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their enrichment in oncogenic promoters and telomeres has generated interest in targeting G-quadruplex (GQ) for an anticancer therapy. Here, we present a quantitative analysis on the conformations and dynam...

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Detalles Bibliográficos
Autores principales: Tippana, Ramreddy, Xiao, Weikun, Myong, Sua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081081/
https://www.ncbi.nlm.nih.gov/pubmed/24920827
http://dx.doi.org/10.1093/nar/gku464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081081/
https://www.ncbi.nlm.nih.gov/pubmed/24920827
http://dx.doi.org/10.1093/nar/gku464

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