TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells

Phosphorothioate (PS) antisense oligonucleotides (ASOs) have been successfully developed as drugs to reduce the expression of disease-causing genes. PS-ASOs can be designed to induce degradation of complementary RNAs via the RNase H pathway and much is understood about that process. However, interac...

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Detalles Bibliográficos
Autores principales: Liang, Xue-hai, Shen, Wen, Sun, Hong, Prakash, Thazha P., Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081088/
https://www.ncbi.nlm.nih.gov/pubmed/24861627
http://dx.doi.org/10.1093/nar/gku484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081088/
https://www.ncbi.nlm.nih.gov/pubmed/24861627
http://dx.doi.org/10.1093/nar/gku484

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