Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry

5-Hydroxymethylcytosine (5hmC) is present in T-even phage and mammalian DNA as well as some nucleoside antibiotics, including mildiomycin and bacimethrin, during whose synthesis 5hmC is produced by the hydrolysis of 5-hydroxymethyl cytidine 5′-monophosphate (hmCMP) by an N-glycosidase MilB. Recently...

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Detalles Bibliográficos
Autores principales: Zhao, Gong, Wu, Geng, Zhang, Yan, Liu, Guang, Han, Tiesheng, Deng, Zixin, He, Xinyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081090/
https://www.ncbi.nlm.nih.gov/pubmed/24920828
http://dx.doi.org/10.1093/nar/gku486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081090/
https://www.ncbi.nlm.nih.gov/pubmed/24920828
http://dx.doi.org/10.1093/nar/gku486

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