Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage

In synthesizing a double-stranded DNA from viral RNA, HIV-1 reverse transcriptase (RT) generates an RNA/DNA intermediate. RT also degrades the RNA strand and synthesizes the second DNA strand. The RNase H active site of RT functions as a nuclease to cleave the RNA strand; however, the structural bas...

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Detalles Bibliográficos
Autores principales: Das, Kalyan, Martinez, Sergio E., Bandwar, Rajiv P., Arnold, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081091/
https://www.ncbi.nlm.nih.gov/pubmed/24880687
http://dx.doi.org/10.1093/nar/gku487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081091/
https://www.ncbi.nlm.nih.gov/pubmed/24880687
http://dx.doi.org/10.1093/nar/gku487

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