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Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters
The p53 tumour suppressor is induced by various stress stimuli and coordinates an adaptive gene expression programme leading to growth arrest or cell death. Some stimuli, such as DNA damage, lead to rapid and substantial multisite phosphorylation of p53, nucleated initially through phosphorylation o...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081099/ https://www.ncbi.nlm.nih.gov/pubmed/24928858 http://dx.doi.org/10.1093/nar/gku501 |