Alkylpurine Glycosylase D Employs DNA Sculpting as a Strategy to Extrude and Excise Damaged Bases

Alkylpurine glycosylase D (AlkD) exhibits a unique base excision strategy. Instead of interacting directly with the lesion, the enzyme engages the non-lesion DNA strand. AlkD induces flipping of the alkylated and opposing base accompanied by DNA stack compression. Since this strategy leaves the alky...

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Detalles Bibliográficos
Autores principales: Kossmann, Bradley, Ivanov, Ivaylo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081403/
https://www.ncbi.nlm.nih.gov/pubmed/24992034
http://dx.doi.org/10.1371/journal.pcbi.1003704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081403/
https://www.ncbi.nlm.nih.gov/pubmed/24992034
http://dx.doi.org/10.1371/journal.pcbi.1003704

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