The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells

BACKGROUND: Activation of Rho, one of the small GTPases, and its major downstream target Rho-kinase (ROCK) promotes the development and metastasis of cancer. We previously showed that elevation of Rho and ROCK expression was associated with tumor invasion, metastasis, and an unfavorable prognosis in...

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Detalles Bibliográficos
Autores principales: Abe, Hideyuki, Kamai, Takao, Hayashi, Keitaro, Anzai, Naohiko, Shirataki, Hiromichi, Mizuno, Tomoya, Yamaguchi, Yoshiyuki, Masuda, Akinori, Yuki, Hideo, Betsunoh, Hironori, Yashi, Masahiro, Fukabori, Yoshitatsu, Yoshida, Ken-Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081468/
https://www.ncbi.nlm.nih.gov/pubmed/24908363
http://dx.doi.org/10.1186/1471-2407-14-412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081468/
https://www.ncbi.nlm.nih.gov/pubmed/24908363
http://dx.doi.org/10.1186/1471-2407-14-412

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