Cargando…

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells

BACKGROUND: Activation of Rho, one of the small GTPases, and its major downstream target Rho-kinase (ROCK) promotes the development and metastasis of cancer. We previously showed that elevation of Rho and ROCK expression was associated with tumor invasion, metastasis, and an unfavorable prognosis in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abe, Hideyuki, Kamai, Takao, Hayashi, Keitaro, Anzai, Naohiko, Shirataki, Hiromichi, Mizuno, Tomoya, Yamaguchi, Yoshiyuki, Masuda, Akinori, Yuki, Hideo, Betsunoh, Hironori, Yashi, Masahiro, Fukabori, Yoshitatsu, Yoshida, Ken-Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081468/ https://www.ncbi.nlm.nih.gov/pubmed/24908363 http://dx.doi.org/10.1186/1471-2407-14-412

Ejemplares similares

Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma
por: Betsunoh, Hironori, et al.
Publicado: (2013)

Axitinib for preoperative downstaging of renal cell carcinoma with sarcomatoid differentiation and direct invasion of the duodenum and inferior vena cava: a case report
por: Yuki, Hideo, et al.
Publicado: (2014)

Prostate volume and biopsy tumor length are significant predictors for classical and redefined insignificant cancer on prostatectomy specimens in Japanese men with favorable pathologic features on biopsy
por: Yashi, Masahiro, et al.
Publicado: (2014)

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma
por: Masuda, Akinori, et al.
Publicado: (2014)

Association of cancer progression with elevated expression of programmed cell death protein 1 ligand 1 by upper tract urothelial carcinoma and increased tumor-infiltrating lymphocyte density
por: Nukui, Akinori, et al.
Publicado: (2020)

Clinically significant association between the maximum standardized uptake value on (18)F-FDG PET and expression of phosphorylated Akt and S6 kinase for prediction of the biological characteristics of renal cell cancer
por: Mizuno, Tomoya, et al.
Publicado: (2015)

Extravasation of Urine Associated with Bilateral Complete Ureteral Duplication, Vesicoureteral Reflux and Benign Prostatic Hyperplasia
por: Suzuki, Issei, et al.
Publicado: (2017)

Utility of whole‐body diffusion‐weighted magnetic resonance imaging in the management of treatment‐related neuroendocrine prostate cancer
por: Kurashina, Ryo, et al.
Publicado: (2020)

Performance characteristics of prostate-specific antigen density and biopsy core details to predict oncological outcome in patients with intermediate to high-risk prostate cancer underwent robot-assisted radical prostatectomy
por: Yashi, Masahiro, et al.
Publicado: (2017)

Elevated serum levels of cardiovascular biomarkers are associated with progression of renal cancer
por: Kamai, Takao, et al.
Publicado: (2018)

Increased Nrf2 expression by renal cell carcinoma is associated with postoperative chronic kidney disease and an unfavorable prognosis
por: Yuki, Hideo, et al.
Publicado: (2018)

Transperitoneal laparoscopic umbilical resection of urachal remnants: a feasible surgical method
por: Yuki, Hideo, et al.
Publicado: (2023)

The Predictive Value of Glycated Hemoglobin and Albumin for the Clinical Course Following Hospitalization of Patients with Febrile Urinary Tract Infection
por: Kobayashi, Minoru, et al.
Publicado: (2018)

Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils.
por: Siomboing, X, et al.
Publicado: (2001)

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease
por: Li, Mei, et al.
Publicado: (2013)

Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer
por: Yamaguchi, Yoshiyuki, et al.
Publicado: (2019)

Serum interferon alpha receptor 2 mRNA may predict efficacy of interferon alpha with/without low-dose sorafenib for metastatic clear cell renal cell carcinoma
por: Furuya, Nobutaka, et al.
Publicado: (2011)

Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition
por: Schmidt, Julie A., et al.
Publicado: (2017)

HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice
por: Lee, Seung-Hoon, et al.
Publicado: (2018)

1077. Heart Transplantation as Salvage Treatment for Intractable Infective Endocarditis
por: Tattevin, Pierre, et al.
Publicado: (2018)

Elevated expression of B7 homolog 4 is associated with disease progression in upper urinary tract urothelial carcinoma
por: Mizuno, Tomoya, et al.
Publicado: (2021)

Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
por: Hayashi, Keitaro, et al.
Publicado: (2017)

Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer
por: Kamai, Takao, et al.
Publicado: (2010)

P1077: HODGKIN LYMPHOMA IN PATIENTS WITH HIV: NATIONAL RETROSPECTIVE MULTICENTER STUDY
por: Chekalov, A., et al.
Publicado: (2022)

1077. Reduce Anti-Microbial Use in Extracorporeal Membrane Oxygenation: Reduce AMMO Study
por: Shah, Aditya, et al.
Publicado: (2019)

Phenotypic expression of the p.Leu1077Pro CFTR mutation in Sicilian cystic fibrosis patients
por: Parisi, Giuseppe Fabio, et al.
Publicado: (2013)

Primary mucosal melanoma of the sinonasal tract: Report of 18 patients and analysis of 1077 patients in the literature
por: Khademi, Bijan, et al.
Publicado: (2015)

5-Fluorouracil-based adjuvant chemotherapy improves the clinical outcomes of patients with lymphovascular invasion of upper urinary tract cancer and low expression of dihydropyrimidine dehydrogenase
por: Narimatsu, Takahiro, et al.
Publicado: (2019)

1077. Understanding the Psychosocial Burden Associated with Hospitalization Among Adults Diagnosed with COVID-19 in the United States
por: Ansari, Wajeeha, et al.
Publicado: (2022)

Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma
por: Kamai, Takao, et al.
Publicado: (2021)

Metformin inhibits urothelial tumorigenesis in the UPII-mutant Ha-ras transgenic mouse model
por: Liu, Zhongbo, et al.
Publicado: (2014)

Prostate-specific antigen kinetics contributes to decision making for biopsy referral: the predictive implication for PSA retest in patients with elevated PSA levels
por: Kobayashi, Minoru, et al.
Publicado: (2023)

Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy
por: Nukui, Akinori, et al.
Publicado: (2017)

Blunted Activation of Rho-Kinase in Yak Pulmonary Circulation
por: Ishizaki, Takeshi, et al.
Publicado: (2015)

Abnormal 18F-FDG uptakes in the prostate due to two different conditions of urine reflux: a mimicker of prostate cancer
por: Inamura, Kensuke, et al.
Publicado: (2016)

1077. Infectious complications after second allogeneic hematopoietic cell transplant (allo-HCT) in adult patients with hematological malignancies
por: Maurer, Stephen, et al.
Publicado: (2020)

Higher preoperative serum levels of PD‐L1 and B7‐H4 are associated with invasive and metastatic potential and predictable for poor response to VEGF‐targeted therapy and unfavorable prognosis of renal cell carcinoma
por: Fukuda, Takehiko, et al.
Publicado: (2016)

Increased co-expression of stromal HHLA2 and fibroblast activation protein in upper tract urothelial carcinoma
por: Nishihara, Daisaku, et al.
Publicado: (2023)

Real-to-imaginary ratio of the $\overline{p}p$ forward elastic scattering amplitude at 550, 757, and 1077 MeV/c
por: Schiavon, R P, et al.
Publicado: (1989)

Assessment of the application for renewal of authorisation of Levucell SC (Saccharomyces cerevisiae CNCM I‐1077) as a feed additive for lambs and horses
por: Bampidis, Vasileios, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_alj6urehvt5t4trraj6l14uop9