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Assessment of the Impact of Using a Reference Transcriptome in Mapping Short RNA-Seq Reads
RNA-Seq has become increasingly popular in transcriptome profiling. The major challenge in RNA-Seq data analysis is the accurate mapping of junction reads to their genomic origins. To detect splicing sites in short reads, many RNA-Seq aligners use reference transcriptome to inform placement of junct...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081564/ https://www.ncbi.nlm.nih.gov/pubmed/24992027 http://dx.doi.org/10.1371/journal.pone.0101374 |