Targeting the Sheddase Activity of ADAM17 by an Anti-ADAM17 Antibody D1(A12) Inhibits Head and Neck Squamous Cell Carcinoma Cell Proliferation and Motility via Blockage of Bradykinin Induced HERs Transactivation

A disintegrin and metalloproteinase 17 (ADAM17) regulates key cellular processes including proliferation and migration through the shedding of a diverse array of substrates such as epidermal growth factor receptor (EGFR) ligands. ADAM17 is implicated in the pathogenesis of many diseases including rh...

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Detalles Bibliográficos
Autores principales: Huang, Yanchao, Benaich, Nathan, Tape, Christopher, Kwok, Hang Fai, Murphy, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081605/
https://www.ncbi.nlm.nih.gov/pubmed/25013379
http://dx.doi.org/10.7150/ijbs.9326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081605/
https://www.ncbi.nlm.nih.gov/pubmed/25013379
http://dx.doi.org/10.7150/ijbs.9326

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