The Roles of Individual Mammalian Argonautes in RNA Interference In Vivo

Argonaute 2 (Ago2) is the only mammalian Ago protein capable of mRNA cleavage. It has been reported that the activity of the short interfering RNA targeting coding sequence (CDS), but not 3′ untranslated region (3′UTR) of an mRNA, is solely dependent on Ago2 in vitro. These studies utilized extremel...

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Detalles Bibliográficos
Autores principales: Ruda, Vera M., Chandwani, Rohit, Sehgal, Alfica, Bogorad, Roman L., Akinc, Akin, Charisse, Klaus, Tarakhovsky, Alexander, Novobrantseva, Tatiana I., Koteliansky, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081796/
https://www.ncbi.nlm.nih.gov/pubmed/24992693
http://dx.doi.org/10.1371/journal.pone.0101749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081796/
https://www.ncbi.nlm.nih.gov/pubmed/24992693
http://dx.doi.org/10.1371/journal.pone.0101749

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