Variation in the Circumsporozoite Protein of Plasmodium falciparum: Vaccine Development Implications

The malaria vaccine candidate RTS,S/AS01 is based on immunogenic regions of Plasmodium falciparum circumsporozoite protein (CSP) from the 3D7 reference strain and has shown modest efficacy against clinical disease in African children. It remains unclear what aspect(s) of the immune response elicited...

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Detalles Bibliográficos
Autores principales: Gandhi, Kavita, Thera, Mahamadou A., Coulibaly, Drissa, Traoré, Karim, Guindo, Ando B., Ouattara, Amed, Takala-Harrison, Shannon, Berry, Andrea A., Doumbo, Ogobara K., Plowe, Christopher V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081809/
https://www.ncbi.nlm.nih.gov/pubmed/24992338
http://dx.doi.org/10.1371/journal.pone.0101783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081809/
https://www.ncbi.nlm.nih.gov/pubmed/24992338
http://dx.doi.org/10.1371/journal.pone.0101783

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