Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

[Image: see text] The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin (H(4)B) molecules in the dimer interacts directly with the heme, and each H(4)B m...

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Detalles Bibliográficos
Autores principales: Chreifi, Georges, Li, Huiying, McInnes, Craig R., Gibson, Colin L., Suckling, Colin J., Poulos, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082377/
https://www.ncbi.nlm.nih.gov/pubmed/24819538
http://dx.doi.org/10.1021/bi5003986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082377/
https://www.ncbi.nlm.nih.gov/pubmed/24819538
http://dx.doi.org/10.1021/bi5003986

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